Behcet’s Disease Presenting with Focal Fibrosing Mediastinitis and SVC Thrombosis: A Case Report with Review of Literature
Abstract
Introduction
Behcet's disease is a rare, multisystemic disease marked by vasculitis and a triad of recurrent oral and genital mucosa ulcers, as well as relapsing uveitis and thrombophlebitis. Mediastinal fibrosis is extremely rare in Behcet's disease.
Case presentation
We present ultrasound and computed tomography (CT scan) in a 26-year male with mediastinal fibrosis and superior vena cava (SVC) thrombosis, with thrombus in left internal jugular veins (IJV) associated with Behcet’s disease.
Conclusion
Behcet's disease can cause mediastinal fibrosis in rare cases. CT and MRI are efficient methods for detecting mediastinal fibrosis and superior vena cava thrombosis.
References
- Mohammed S, Kakamad F, Tahir S, Hassan M, Hassan M, Abdalla B, Hussein D, Ahmed S. May-Thurner syndrome as the presenting symptoms of Behcet’s disease; a rare case report. BARW MEDICAL JOURNAL. 2023; 1(1). doi:N/A
- Harman M, Sayarlioglu M, Arslan H, Ayakta H, Harman E. Fibrosing mediastinitis and thrombosis of superior vena cava associated with Behcet's disease. European journal of radiology. 2003;48(2):209-12. doi:10.1016/S0720-048X(03)00006-8
- Kanne JP, Mohammed T-LH. Fibrosing mediastinitis associated with Behçet's disease: CT findings. Clinical radiology. 2007;62(11):1124-6. doi:10.1016/j.crad.2007.07.007
- de Paiva TF, Ribeiro HB, Campanholo CB, Gonçalves CR, Terigoe DY, de Souza BDB. Behçet’s disease associated with superior vena cava syndrome without thrombosis. Clinical rheumatology. 2007;26(5):804-6. doi:10.1007/s10067-006-0241-2
- Garrana SH, Buckley JR, Rosado-de-Christenson ML, Martínez-Jiménez S, Muñoz P, Borsa JJ. Multimodality imaging of focal and diffuse fibrosing mediastinitis. Radiographics. 2019;39(3):651-67. doi:10.1148/rg.2019180143
- Deshwal H, Ghosh S, Magruder K, Bartholomew JR, Montgomery J, Mehta AC. A review of endovascular stenting for superior vena cava syndrome in fibrosing mediastinitis. Vascular Medicine. 2020;25(2):174-83. doi:10.1177/1358863X19884130
- Sarr SA, Fall PD, Mboup MC, Dia K, Bodian M, Jobe M. Superior vena cava syndrome revealing a Behçet’s disease. Thrombosis Journal. 2015;13(1):1-4. doi:10.1186/s12959-015-0039-z
- Tabotta F, Ferretti GR, Prosch H, Boussouar S, Brun A-L, Roos JE, et al. Imaging features and differential diagnoses of non-neoplastic diffuse mediastinal diseases. Insights into imaging. 2020;11(1):1-12. doi:10.1186/s13244-020-00909-z
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