Abdulwahid M. Salih
Faculty of Medical Sciences, School of Medicine, University of Sulaimani, Sulaimani, Kurdistan, Iraq
Hawbash M. Rahim
Medical Laboratory Science Department, Komar University of Science and Technology, Sulaymaniyah, Kurdistan, Iraq
Berun A. Abdalla
Kscien Organization for Scientific Research (Middle East office), Hamid Str, Azadi Mall, Sulaimani, Kurdstan, Iraq
Fahmi H. Kakamad
Kscien Organization for Scientific Research (Middle East office), Hamid Str, Azadi Mall, Sulaimani, Kurdstan, Iraq
Usra A. Mhamad
Kscien Organization for Scientific Research (Middle East office), Hamid Str, Azadi Mall, Sulaimani, Kurdstan, Iraq
Gasha S. Ahmed
Kscien Organization for Scientific Research (Middle East office), Hamid Str, Azadi Mall, Sulaimani, Kurdstan, Iraq
Hiwa O. Abdulla
Smart Health Tower, Scientific Affairs Department, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq
Han Aube
Faculty of Medical Sciences, School of Medicine, University of Sulaimani, Sulaimani, Kurdistan, Iraq
Hiwa O. Baba
Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq
Ekram K. Mustafa
Kscien Organization for Scientific Research (Middle East office), Hamid Str, Azadi Mall, Sulaimani, Kurdstan, Iraq
Lawand M. Ahmed
Kscien Organization for Scientific Research (Middle East office), Hamid Str, Azadi Mall, Sulaimani, Kurdstan, Iraq
Shvan H. Mohammed
Kscien Organization for Scientific Research (Middle East office), Hamid Str, Azadi Mall, Sulaimani, Kurdstan, Iraq
Fakher Abdullah
Kscien Organization for Scientific Research (Europe office), Verboomstraat 175b, 3082 jj Rotterdam, Netherlands
Keywords
Pilonidal sinus disease, Rat, Induction, Drugs
Abstract
Introduction
Pilonidal sinus disease is a common suppurative perianal condition. The aim of this trial is to create an animal model of pilonidal sinus disease to study and compare the mechanism of action of numerous medications.
Methods
Ten adult Sprague-Dawley rats were enrolled in the study. They were separately housed in polypropylene cages. They were fed normal chow. The rats were anesthetized with Ketamine and Xylazine (At a ratio of 3:1) through intramuscular injection into their proximal thigh. The back of each rat was shaved, and a sample of the hair rat was obtained and labeled. After clearing the back of the animal, a vertical 1 cm incision was inflicted upon the dorsal side of each rat with a blade 15’ and a tuft of hair composed of at least 20 fibers was embedded in the wound, later the wound was closed by 4.0 proline suture material in a simple interrupted fashion. The rats were followed for a period of 4 weeks.
Results
Macroscopically, the rats showed 0.5x0.5 cm nodules at the side of the injury at the 5th week. As there was no draining sinus, the picture in this form cannot be regarded as a typical pilonidal sinus, it was more consistent with a foreign body granuloma. No pilonidal sinus could be reported.
Conclusion
Rat is not a suitable animal for the induction of pilonidal sinus disease.
Abstract