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Thyroid Collision Tumors: A Systematic Review

Ari M. Abdullah
Department of Pathology, Sulaymaniyah Teaching Hospital, Sulaymaniyah, Kurdistan, Iraq
Aras J. Qaradakhy
Department of Radiology, Shorsh Teaching Hospital, Sulaymaniyah, Kurdistan, Iraq
Rawa M. Ali
Hospital for Treatment of Victims of Chemical Weapons, Halabja, Kurdistan, Iraq
Rebaz M. Ali
Hiwa Cancer Hospital, Sulaimani Directorate of Health, Sulaymaniyah, Kurdistan, Iraq
Yousif M. Mahmood
Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq
Sami S. Omar
Rizgary Oncology Center, Peshawa Qazi Street, Erbil, Kurdistan, Iraq
Hawkar A. Nasralla
Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq
Aso S. Muhialdeen
Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq
Yadgar A. Saeed
Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq
Hardi M. Dhair
Hospital for Treatment of Victims of Chemical Weapons, Halabja, Kurdistan, Iraq
Rebaz O. Mohammed
Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq
Hiwa O. Baba
Kscien Organization for Scientific Research (Middle East Office), Hamid Street, Azadi Mall, Sulaymaniyah, Kurdistan, Iraq
Berun A. Abdalla
Department of Biology, College of Education, University of Sulaimani, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq
Fahmi H. Kakamad
College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq
Abdulwahid M. Salih
College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq
Abstract
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Published: June 28, 2024
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Abstract

Introduction

Collision tumors in the thyroid gland are exceedingly uncommon, comprising approximately 1.0% of all thyroid malignancies. This study aims to systematically review the presentation and management of collision tumors of the thyroid gland.

Methods

A systematic review of published studies on thyroid collision tumors was conducted. All studies concerning thyroid collision tumors meeting the following criteria were included: 1) Confirmation of collision tumors via diagnostic methods, surgical exploration, or histopathological examination. 2) Presentation of case details within the study. 3) Tumors located precisely in the thyroid gland.

Results

In total, 57 studies were compatible with the inclusion criteria. Most cases were female 87 (71.31%), and the remaining 35 (28.69%) were male. The patients' ages were between 12 and 88 years old, with a mean of 49.87 ± 14.48 years. The most commonly presented symptom was neck swelling (45.08%). The most prevalent surgical procedure observed was total thyroidectomy combined with lymph node dissection, performed in 40 cases (32.78%). The predominant histopathological findings consisted of the simultaneous presence of papillary thyroid carcinoma and medullary thyroid carcinoma, identified in 51 cases (41.80%). The recurrence rate was observed in only 10 cases (8.20%).

Conclusion

Thyroid collision tumors may primarily affect females, with the most frequent collisions being papillary and medullary thyroid carcinoma. Total thyroidectomy with lymph node dissection is the prevalent management option, and the recurrence rate can be lower than 10%.

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